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Cannabis Metabolism & Edibles Guide
Feb
Cannabis Metabolism & Edibles Guide: How Your Body Processes THC
Understanding how your body metabolizes cannabis is key to safe, effective edible use. Unlike smoking or vaping, edibles pass through the digestive system and liver before reaching the bloodstream, creating unique effects in both intensity and duration.
This guide explains cannabis metabolism, how edibles are processed, factors affecting effects, and practical tips for safe dosing.
How Cannabis Is Metabolized in the Body
When you consume THC edibles:
THC is digested in the stomach
Absorbed in the intestines
Travels to the liver
Converted into 11-hydroxy-THC, a more potent form
Enters the bloodstream and reaches the brain
Edible Cannabis Onset vs Smoking/Vaping
| Method | Onset Time | Peak | Duration |
|---|---|---|---|
| Edibles | 30–120 min | 2–4 hrs | 6–8+ hrs |
| Smoking | 2–10 min | 30–60 min | 2–4 hrs |
| Vaping | 2–5 min | 30–60 min | 2–4 hrs |
Key takeaway: Edibles take longer to start but often feel stronger and last longer due to liver metabolism.
Factors That Affect Cannabis Metabolism
1. Dosage
Higher doses take longer to metabolize and often produce stronger effects.
2. Tolerance
Regular users may process THC faster and feel shorter effects.
3. Body Weight & Fat
THC is lipophilic (stored in fat), affecting duration and intensity.
4. Food Intake
Empty stomach: faster, stronger effects
Full stomach: slower, milder effects
5. Enzymes & Genetics
Individual liver enzyme activity can affect how quickly THC converts to 11-hydroxy-THC.
THC & CBD Metabolism Differences
| Compound | Metabolism Pathway | Effect Duration |
|---|---|---|
| THC | Liver → 11-hydroxy-THC | Long-lasting, psychoactive |
| CBD | Liver → inactive metabolites | Non-psychoactive, moderate duration |
Edible Dosing & Safety Tips
| Experience Level | Suggested Dose |
|---|---|
| Beginner | 2.5–5 mg THC |
| Occasional User | 5–10 mg THC |
| Experienced | 10–20 mg THC |
| High Tolerance | 20+ mg THC (use caution) |
Tips:
Always wait 2 hours before taking more
Avoid mixing with alcohol
Keep in a safe environment
Track your personal response
Cannabis Metabolism FAQ
How long does it take for edibles to kick in?
30–120 minutes, depending on metabolism, stomach contents, and dose.
Why do edibles feel stronger than smoking?
The liver converts THC into 11-hydroxy-THC, which crosses the blood-brain barrier more efficiently.
How long do edible effects last?
6–8 hours on average, with residual effects up to 24 hours in some cases.
Can CBD affect THC metabolism?
Yes CBD can slow THC metabolism slightly, altering onset and intensity.
Does eating before an edible matter?
Yes a full stomach delays onset but smooths the experience; an empty stomach speeds onset but can feel stronger.
Final Thoughts
Understanding cannabis metabolism is essential for safe and enjoyable edible use. By knowing how your body processes THC and CBD, you can:
Predict onset and peak effects
Avoid overconsumption
Choose the right dose and timing
Maximize desired effects safely
